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Article

Biological significance of promoter hypermethylation of p14/ARF gene: relationships to p53 mutational status in Tunisian population with colorectal carcinoma.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Feb 2014

Chaar Ines, Amara Sameh, Elamine Olfa Elhadj, Khiari Mariem, Ounissi Donia, Khalfallah Taher, Ben Hmida Abdelmajid, Mzabi Sabeh, Bouraoui Saadia

Abstract excerpt

One of the most important pathways which are frequently affected in colorectal cancer is p53/ (MDM2)/p14ARF pathway. We aim to determine the methylation pattern of p14/ARF in relation to mutation of p53. This correlation was studied to investigate whether their alterations could be considered as a predictor factor of prognosis in colorectal cancer and whether it can be useful in early-stage diagnosis. Statistical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24065196
DOI: 10.1007/s13277-013-1198-9
PMCID: PMC3932170

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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