Article
The novel TP53 3'-end methylation pattern associated with its expression would be a potential biomarker for breast cancer detection.
Breast cancer research and treatment - 1 Feb 2020
Zeng Feng, Heng Jianfu, Guo Xinwu, Wang Yue, Wu Wenhan, Tang Lili, Chen Min, Wang Shouman, Deng Hongyu, Wang Jun
Abstract excerpt
BACKGROUND: Deficiency or silence of TP53 is an early event in breast tumorigenesis. Aberrant methylation and mutation in regulatory regions were considered as crucial regulators of gene expression. METHODS: Using multiplex-PCR and next-generation sequencing technology, we analyzed TP53 mutation spectrum in its promoter region. Using PCR target sequence enrichment and next-generation bisulfite sequencing...
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