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Article

Association of the CCR5 gene with juvenile idiopathic arthritis.

Genes and immunity - 1 Oct 2010

Hinks A, Martin P, Flynn E, Eyre S, Packham J, Barton A, Worthington J, Thomson W

Abstract excerpt

The CC chemokine receptor 5 (CCR5) has been shown to be important in the recruitment of T-helper cells to the synovium, where they accumulate, drive the inflammatory process and the consequent synovitis and joint destruction. A 32 base-pair insertion/deletion variant (CCR5Δ32) within the gene leads to a frame shift and a nonfunctional receptor. CCR5Δ32 has been investigated for its association with juvenile...

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Identifiers

PMID: 20463745
DOI: 10.1038/gene.2010.25
PMCID: PMC2974598

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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