Article
Lack of association between the chemokine receptor 5 polymorphism CCR5delta32 in rheumatoid arthritis and juvenile idiopathic arthritis.
BMC medical genetics - 12 Jun 2007
Lindner Ewald, Nordang Gry B N, Melum Espen, Flatø Berit, Selvaag Anne Marit, Thorsby Erik, Kvien Tore K, Førre Oystein T, Lie Benedicte A
Abstract excerpt
BACKGROUND: The chemokine receptor CCR5 has been detected at elevated levels on synovial T cells, and a 32 bp deletion in the CCR5 gene leads to a non-functional receptor. A negative association between the CCR5Delta32 and rheumatoid arthritis (RA) has been reported, although with conflicting results. In juvenile idiopathic arthritis (JIA), an association with CCR5 was recently reported. The purpose of this study...
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