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Article

Association of two functional polymorphisms in the CCR5 gene with juvenile rheumatoid arthritis.

Genes and immunity - 1 Sept 2006

Prahalad S, Bohnsack J F, Jorde L B, Whiting A, Clifford B, Dunn D, Weiss R, Moroldo M, Thompson S D, Glass D N, Bamshad M J

Abstract excerpt

Juvenile rheumatoid arthritis (JRA) is mediated by Th1-immune responses. In children with JRA, synovial T cells express high levels of the Th1-chemokine receptor CC chemokine receptor 5 (CCR5), which has been implicated in susceptibility to rheumatoid arthritis. To test the hypothesis that genetic variation in CCR5 is associated with susceptibility to JRA, we analyzed patterns of variation in the 5'cis-regulatory...

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Share to Arthritis, Juvenile
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child, Preschool

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Share to Polymorphism, Genetic

Share to Receptors, CCR5

Source

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Identifiers

PMID: 16775617
DOI: 10.1038/sj.gene.6364317
PMCID: PMC2927816

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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