Article
Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility.
BMC medical genetics - 22 Mar 2016
Finkel Terri H, Li Jin, Wei Zhi, Wang Wei, Zhang Haitao, Behrens Edward M, Reuschel Emma L, Limou Sophie, Wise Carol, Punaro Marilynn, Becker Mara L, Munro Jane E, Flatø Berit, Førre Øystein, Thompson Susan D, Langefeld Carl D, Glass David N, Glessner Joseph T, Kim Cecilia E, Frackelton Edward, Shivers Debra K, Thomas Kelly A, Chiavacci Rosetta M, Hou Cuiping, Xu Kexiang, Snyder James, Qiu Haijun, Mentch Frank, Wang Kai, Winkler Cheryl A, Lie Benedicte A, Ellis Justine A, Hakonarson Hakon
Abstract excerpt
BACKGROUND: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease among children, the etiology of which involves a strong genetic component, but much of the underlying genetic determinants still remain unknown. Our aim was to identify novel genetic variants that predispose to JIA. METHODS: We performed a genome-wide association study (GWAS) and replication in a total of 1166 JIA cases...
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