Article
CCR5 and CCR5Δ32 in bacterial and parasitic infections: Thinking chemokine receptors outside the HIV box.
International journal of immunogenetics - 1 Jun 2020
Ellwanger Joel Henrique, Kaminski Valéria de Lima, Rodrigues Andressa Gonçalves, Kulmann-Leal Bruna, Chies José Artur Bogo
Abstract excerpt
The CCR5 molecule was reported in 1996 as the main HIV-1 co-receptor. In that same year, the CCR5Δ32 genetic variant was described as a strong protective factor against HIV-1 infection. These findings led to extensive research regarding the CCR5, culminating in critical scientific advances, such as the development of CCR5 inhibitors for the treatment of HIV infection. Recently, the research landscape surrounding...
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