Article
Association of rheumatoid arthritis with a functional chemokine receptor, CCR5.
Arthritis and rheumatism - 1 May 1999
Gómez-Reino J J, Pablos J L, Carreira P E, Santiago B, Serrano L, Vicario J L, Balsa A, Figueroa M, de Juan M D
Abstract excerpt
OBJECTIVE: To investigate whether the pathogenesis of rheumatoid arthritis (RA) is associated with the functional chemokine receptor CCR5, which is the primary CC chemokine receptor expressed by T cells in rheumatoid synovium, and its nonfunctional receptor, delta32CCR5, which is generated by the homozygous 32-basepair deletion (delta32) in the CCR5 gene. METHODS: The frequency of the CCR5 genotype was compared...
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