Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene.

doi:10.1164/rccm.200910-1586OC

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Article

Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene.

American journal of respiratory and critical care medicine - 1 Sept 2010

Hersh Craig P, Pillai Sreekumar G, Zhu Guohua, Lomas David A, Bakke Per, Gulsvik Amund, DeMeo Dawn L, Klanderman Barbara J, Lazarus Ross, Litonjua Augusto A, Sparrow David, Reilly John J, Agusti Alvar, Calverley Peter M A, Donner Claudio F, Levy Robert D, Make Barry J, Paré Peter D, Rennard Stephen I, Vestbo Jørgen, Wouters Emiel F M, Scholand Mary Beth, Coon Hilary, Hoidal John, Silverman Edwin K

Abstract excerpt

RATIONALE: Several family-based studies have identified genetic linkage for lung function and airflow obstruction to chromosome 2q. OBJECTIVES: We hypothesized that merging results of high-resolution single nucleotide polymorphism (SNP) mapping in four separate populations would lead to the identification of chronic obstructive pulmonary disease (COPD) susceptibility genes on chromosome 2q. METHODS: Within the...

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Identifiers

PMID: 20463177
DOI: 10.1164/rccm.200910-1586OC
PMCID: PMC2937234

Genes

XRCC5

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