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Article

Exon sequencing identifies a novel CHRNA3-CHRNA5-CHRNB4 variant that increases the risk for chronic obstructive pulmonary disease.

Respirology (Carlton, Vic.) - 1 Jul 2015

Zhao Zhuxiang, Peng Fang, Zhou Yumin, Hu Guoping, He Hua, He Fang, Zou Weifeng, Zhao Ziwen, Li Bing, Ran Pixin

Abstract excerpt

BACKGROUND AND OBJECTIVE: Recent genome-wide association studies have established that single nucleotide polymorphisms in the CHRNA3-CHRNA5-CHRNB4 genes are susceptibility loci for chronic obstructive pulmonary disease COPD. However, further effort is still required to reveal their genetic contribution to COPD, considering the existence of 'missing heritability', which may be mediated by variants that are of a...

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Source

Identifiers

PMID: 25891420
DOI: 10.1111/resp.12539

Genes

CHRNA3
CHRNA5
CHRNB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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