Article
X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study.
Respiratory research - 1 Feb 2023
Hayden Lystra P, Hobbs Brian D, Busch Robert, Cho Michael H, Liu Ming, Lopes-Ramos Camila M, Lomas David A, Bakke Per, Gulsvik Amund, Silverman Edwin K, Crapo James D, Beaty Terri H, Laird Nan M, Lange Christoph, DeMeo Dawn L
Abstract excerpt
BACKGROUND: The association between genetic variants on the X chromosome to risk of COPD has not been fully explored. We hypothesize that the X chromosome harbors variants important in determining risk of COPD related phenotypes and may drive sex differences in COPD manifestations. METHODS: Using X chromosome data from three COPD-enriched cohorts of adult smokers, we performed X chromosome specific quality...
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