Article
Association of N176K and L141F dimorphisms of the PRNP gene with lack of pathological prion protein deposition in placentas of naturally and experimentally scrapie-affected ARQ/ARQ sheep.
The Journal of general virology - 1 Sept 2010
Santucciu Cinzia, Maestrale Caterina, Madau Laura, Attene Sonia, Cancedda Maria Giovanna, Demontis Franca, Tilocca Maria Giovanna, Saba Mariangela, Macciocu Simona, Carta Antonello, Ligios Ciriaco
Abstract excerpt
The placenta is important in the horizontal transmission of the aetiological agent in scrapie-affected sheep. It has been demonstrated that the placentas of fetuses carrying the dimorphism Q171R of the PRNP gene is resistant to pathological prion protein (PrP(Sc)) accumulation in the placenta. To...
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