Article
Dynamics and genetics of PrPSc placental accumulation in sheep.
The Journal of general virology - 1 Mar 2007
Lacroux C, Corbière F, Tabouret G, Lugan S, Costes P, Mathey J, Delmas J M, Weisbecker J L, Foucras G, Cassard H, Elsen J M, Schelcher F, Andréoletti O
Abstract excerpt
Placentae from scrapie-affected ewes are an important source of contamination. This study confirmed that scrapie-incubating ewes bearing susceptible genotypes could produce both abnormal prion protein (PrPSc)-positive and -negative placentae, depending only on the PRP genotype of the fetus. The results also provided evidence indicating that scrapie-incubating ARR/VRQ ewes may be unable to accumulate prions in the...
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