Article
Dose-dependent effects of UVB-induced skin carcinogenesis in hairless p53 knockout mice.
Mutation research - 1 Apr 2005
van Kranen Henk J, Westerman Anja, Berg Rob J W, Kram Nicolien, van Kreijl Coen F, Wester Piet W, de Gruijl Frank R
Abstract excerpt
Exposure to (solar) UVB radiation gives rise to mutations in the p53 tumor suppressor gene that appear to contribute to the earliest steps in the molecular cascade towards human and murine skin cancer. To examine in more detail the role of p53, we studied UVB-induced carcinogenesis in hairless p53 knock-out mice. The early onset of lymphomas as well as early wasting of mice interfered with the development of skin...
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