Article
Tagging single nucleotide polymorphisms in phosphoinositide-3-kinase-related protein kinase genes involved in DNA damage "checkpoints" and lung cancer susceptibility.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2008
Hu Zhibin, Liu Hongliang, Wang Haifeng, Miao Ruifen, Sun Weiwei, Jin Guangfu, Wang Ying, Ma Hongxia, Jin Li, Wei Qingyi, Lu Daru, Huang Wei, Shen Hongbing
Abstract excerpt
PURPOSE: DNA damage checkpoints are initiated by its sensor proteins of the phosphoinositide-3-kinase-related protein kinase family, including ataxia-telangiectasia mutated, ataxia-telangiectasia and Rad3-related, and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). We hypothesized that polymorphisms in these genes may alter the regulation of DNA repair and the risk of lung cancer. EXPERIMENTAL DESIGN:...
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