High population frequencies of MICA copy number variations originate from independent recombination events

Abstract excerpt

<title>Abstract</title> <p>MICA is a stress-induced ligand of the NKG2D receptor that stimulates NK and T cell responses and was identified as a key determinant of anti-tumor immunity. The MICA gene is located inside the MHC complex and is in strong linkage disequilibrium with HLA-B. While an HLA-B*48-linked MICA deletion-haplotype was previously described in Asian populations, little is known about other MICA co...

Topics

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• Chromosomes, Human, Pair 6
• Gene Deletion
• Genetics, Population
• Haplotypes
• Histocompatibility Antigens Class I
• HLA-B Antigens
• Killer Cells, Natural
• Linkage Disequilibrium

Identifiers and source

Literature Corpus work

099c26aa-1766-5447-b4d0-82fd31d47461

DOI

10.21203/rs.3.rs-3192282/v1