Autocrine induction of invasive and metastatic phenotypes by the MIF-CXCR4 axis in drug-resistant human colon cancer cells.

doi:10.1158/0008-5472.CAN-09-3828

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Article

Autocrine induction of invasive and metastatic phenotypes by the MIF-CXCR4 axis in drug-resistant human colon cancer cells.

Cancer research - 1 Jun 2010

Dessein Anne-Frédérique, Stechly Laurence, Jonckheere Nicolas, Dumont Patrick, Monté Didier, Leteurtre Emmanuelle, Truant Stéphanie, Pruvot François-René, Figeac Martin, Hebbar Mohamed, Lecellier Charles-Henri, Lesuffleur Thécla, Dessein Rodrigue, Grard Georges, Dejonghe Marie-José, de Launoit Yvan, Furuichi Yasuhiro, Prévost Grégoire, Porchet Nicole, Gespach Christian, Huet Guillemette

Abstract excerpt

Metastasis and drug resistance are major problems in cancer chemotherapy. The purpose of this work was to analyze the molecular mechanisms underlying the invasive potential of drug-resistant colon carcinoma cells. Cellular models included the parental HT-29 cell line and its drug-resistant derivatives selected after chronic treatment with either 5-fluorouracil, methotrexate, doxorubicin, or oxaliplatin....

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Identifiers

PMID: 20460542
DOI: 10.1158/0008-5472.CAN-09-3828

Genes

CXCR4
MIF
ASCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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