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Article

Hypoxia differentially regulated CXCR4 and CXCR7 signaling in colon cancer

14 Mar 2014

Abstract excerpt

BACKGROUND: HIF-1α and CXCR4/CXCL12 have crucial roles in the metastatic process of colorectal cancer. Our aim was to study the significance of targeting HIF-1α and the CXCR4/CXCL12 axis in colorectal cancer to prevent the dissemination process in vitro. METHODS: We investigated CXCR4 and CXCR7 mRNA and protein expression in human colon carcinomas and the modulation of their expression by hypoxia and HIF-1α in...

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PMID: 24629239
DOI: 10.1186/1476-4598-13-58

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