Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fascin, a Novel Target of β-Catenin-TCF Signaling, Is Expressed at the Invasive Front of Human Colon Cancer

15 Jul 2007

Abstract excerpt

Cancer cells become metastatic by acquiring a motile and invasive phenotype. This step requires remodeling of the actin cytoskeleton and the expression of exploratory, sensory organelles known as filopodia. Aberrant beta-catenin-TCF target gene activation plays a major role in colorectal cancer development. We identified fascin1, a key component of filopodia, as a target of beta-catenin-TCF signaling in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cellular Mechanics and Interactions
Share to Hippo pathway signaling and YAP/TAZ

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17638895
DOI: 10.1158/0008-5472.can-07-0929

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fascin, a Novel Target of β-Catenin-TCF Signaling, Is Expressed at the Invasive Front of Human Colon CancerPMID 17638895Read ↗

Roles of fascin in human carcinoma motility and signaling: Prospects for a novel biomarker?Semantic proximity Read ↗

FMNL2 is a positive regulator of cell motility and metastasis in colorectal carcinomaSemantic proximity Read ↗

Furin sustains tumor-promoting signals in KRAS- and BRAF-mutated colorectal cancer by engaging the TGF-β1-COX-2 axis in a reciprocal regulatory network.Semantic proximity Read ↗

Differential involvement of destrin and cofilin‐1 in the control of invasive properties of Isreco1 human colon cancer cellsSemantic proximity Read ↗

Fascin Is a Key Regulator of Breast Cancer Invasion That Acts via the Modification of Metastasis-Associated MoleculesSemantic proximity Read ↗

CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasivenessSemantic proximity Read ↗

FAT1: a potential target for monoclonal antibody therapy in colon cancer.Semantic proximity Read ↗

B-Raf Inhibitors Induce Epithelial Differentiation in <i>BRAF</i> -Mutant Colorectal Cancer CellsSemantic proximity Read ↗

herg1 Gene and HERG1 Protein Are Overexpressed in Colorectal Cancers and Regulate Cell Invasion of Tumor CellsSemantic proximity Read ↗

Widespread FRA1-Dependent Control of Mesenchymal Transdifferentiation Programs in Colorectal Cancer CellsSemantic proximity Read ↗

Fascin in Gynecological Cancers: An Update of the LiteratureSemantic proximity Read ↗

The ß-catenin-target Fascin-1, altering hepatocyte differentiation, is a new marker of immature cells in hepatoblastomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.