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Article

EMT-mediated regulation of CXCL1/5 for resistance to anti-EGFR therapy in colorectal cancer.

Oncogene - 1 Apr 2022

Park Ye-Lim, Kim Hwang-Phill, Ock Chan-Young, Min Dong-Wook, Kang Jun Kyu, Lim Yoo Joo, Song Sang-Hyun, Han Sae-Won, Kim Tae-You

Abstract excerpt

The emergence of RAS/RAF mutant clone is the main feature of EGFR inhibitor resistance in KRAS wild-type colon cancer. However, its molecular mechanism is thought to be multifactorial, mainly due to cellular heterogeneity. In order to better understand the resistance mechanism in a single clone level, we successfully isolated nine cells with cetuximab-resistant (CR) clonality from in vitro system. All CR cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

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Identifiers

PMID: 35173310
DOI: 10.1038/s41388-021-01920-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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