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Article

Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions.

Nucleic acids research - 1 Sept 2010

Yu Amy Marie, McVey Mitch

Abstract excerpt

Ku or DNA ligase 4-independent alternative end joining (alt-EJ) repair of DNA double-strand breaks (DSBs) frequently correlates with increased junctional microhomology. However, alt-EJ also produces junctions without microhomology (apparent blunt joins), and the exact role of microhomology in both alt-EJ and classical non-homologous end joining (NHEJ) remains unclear. To better understand the degree to which...

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Share to DNA Breaks, Double-Stranded
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20460465
DOI: 10.1093/nar/gkq379
PMCID: PMC2943611

Genes

POLQ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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