Article
End-joining repair of double-strand breaks in Drosophila melanogaster is largely DNA ligase IV independent.
Genetics - 1 Dec 2004
McVey Mitch, Radut Dora, Sekelsky Jeff J
Abstract excerpt
Repair of DNA double-strand breaks can occur by either nonhomologous end joining or homologous recombination. Most nonhomologous end joining requires a specialized ligase, DNA ligase IV (Lig4). In Drosophila melanogaster, double-strand breaks created by excision of a P element are usually repaired by a homologous recombination pathway called synthesis-dependent strand annealing (SDSA). SDSA requires strand...
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