Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2.

doi:10.1093/hmg/ddq196

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Article

Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2.

Human molecular genetics - 15 Jul 2010

Garcia-Barceló Maria-Mercè, Yeung Ming-Yiu, Miao Xiao-Ping, Tang Clara Sze-Man, Cheng Guo, Chen Guo, So Man-Ting, Ngan Elly Sau-Wai, Lui Vincent Chi-Hang, Chen Yan, Liu Xue-Lai, Hui Kenneth-Jeremy W S, Li Long, Guo Wei-Hong, Sun Xiao-Bin, Tou Jin-Fa, Chan Kin-Wai, Wu Xuan-Zhao, Song You-Qiang, Chan Danny, Cheung Kenneth, Chung Patrick Ho-Yu, Wong Kenneth Kak-Yuen, Sham Pak-Chung, Cherny Stacey S, Tam Paul Kwong-Hang

Abstract excerpt

Biliary atresia (BA) is characterized by the progressive fibrosclerosing obliteration of the extrahepatic biliary system during the first few weeks of life. Despite early diagnosis and prompt surgical intervention, the disease progresses to cirrhosis in many patients. The current theory for the pathogenesis of BA proposes that during the perinatal period, a still unknown exogenous factor meets the innate immune...

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PMID: 20460270
DOI: 10.1093/hmg/ddq196
PMCID: PMC2893814

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XPNPEP1

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