Common genetic variants regulating ADD3 gene expression alter biliary atresia risk.

doi:10.1016/j.jhep.2013.07.021

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Article

Common genetic variants regulating ADD3 gene expression alter biliary atresia risk.

Journal of hepatology - 1 Dec 2013

Cheng Guo, Tang Clara Sze-Man, Wong Emily Hoi-Man, Cheng William Wai-Chun, So Man-Ting, Miao Xiaoping, Zhang Ruizhong, Cui Long, Liu Xuelai, Ngan Elly Sau-Wai, Lui Vincent Chi-Hang, Chung Patrick Ho-Yu, Chan Ivy Hau-Yee, Liu Juncheng, Zhong Wei, Xia Huimin, Yu Jiakang, Qiu Xiu, Wu Xuan-Zhao, Wang Bin, Dong Xiao, Tou Jinfa, Huang Liuming, Yi Bin, Ren Hongxia, Chan Edwin Kin-Wai, Ye Kenny, O'Reilly Paul F, Wong Kenneth Kak-Yuen, Sham Pak-Chung, Cherny Stacey S, Tam Paul Kwong-Hang, Garcia-Barceló Maria-Mercè

Abstract excerpt

BACKGROUND & AIMS: Biliary atresia (BA) is a rare and most severe cholestatic disease in neonates, but the pathogenic mechanisms are unknown. Through a previous genome wide association study (GWAS) on Han Chinese, we discovered association of the 10q24.2 region encompassing ADD3 and XPNPEP1 genes, which was replicated in Chinese and Thai populations. This study aims to fully characterize the genetic architecture...

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Identifiers

PMID: 23872602
DOI: 10.1016/j.jhep.2013.07.021

Genes

ADD3
XPNPEP1

Provenance

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