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Article

Immune and genetic landscapes of biliary atresia: a pathway to precision medicine.

BMC pediatrics - 15 Jul 2025

Lv Chao, Qi Chengang, Dai Xiaoke, Zhang Mingman

Abstract excerpt

BACKGROUND: Biliary atresia (BA) is a rare pediatric cholestatic disorder characterized by progressive bile duct inflammation and fibrosis. The underlying molecular mechanisms of BA remain poorly defined. This study aimed to identify susceptibility genes causally associated with BA by integrating genome-wide association study (GWAS) and transcriptomic data, and to explore their potential immunopathological roles....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40665272
DOI: 10.1186/s12887-025-05893-1
PMCID: PMC12261710

Genes

CHIT1
PSD3
TCEA3
CRIM1
MAPRE3
SEC14L4

Provenance

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