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Article

Replication of a GWAS signal in a Caucasian population implicates ADD3 in susceptibility to biliary atresia.

Human genetics - 1 Feb 2014

Tsai Ellen A, Grochowski Christopher M, Loomes Kathleen M, Bessho Kazuhiko, Hakonarson Hakon, Bezerra Jorge A, Russo Pierre A, Haber Barbara A, Spinner Nancy B, Devoto Marcella

Abstract excerpt

In the United States, biliary atresia (BA) is the most frequent indication for liver transplantation in pediatric patients. BA is a complex disease, with suspected environmental and genetic risk factors. A genome-wide association study in Chinese patients identified association to the 10q24.2 (hg18) genomic region. This signal was upstream of two genes, XPNPEP1 and ADD3, both expressed in intrahepatic bile ducts....

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Source

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Identifiers

PMID: 24104524
DOI: 10.1007/s00439-013-1368-2
PMCID: PMC3901047

Genes

ADD3
XPNPEP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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