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Article

Novel findings from family-based exome sequencing for children with biliary atresia.

Scientific reports - 8 Nov 2021

Tran Kien Trung, Le Vinh Sy, Dao Lan Thi Mai, Nguyen Huyen Khanh, Mai Anh Kieu, Nguyen Ha Thi, Ngo Minh Duy, Tran Quynh Anh, Nguyen Liem Thanh

Abstract excerpt

Biliary atresia (BA) is a progressive inflammation and fibrosis of the biliary tree characterized by the obstruction of bile flow, which results in liver failure, scarring and cirrhosis. This study aimed to explore the elusive aetiology of BA by conducting whole exome sequencing for 41 children with BA and their parents (35 trios, including 1 family with 2 BA-diagnosed children and 5 child-mother cases). We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34750413
DOI: 10.1038/s41598-021-01148-y
PMCID: PMC8575792

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