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Article

CXCR4-independent rescue of the myeloproliferative defect of the Gata1low myelofibrosis mouse model by Aplidin.

Journal of cellular physiology - 1 Nov 2010

Verrucci Maria, Pancrazzi Alessandro, Aracil Miguel, Martelli Fabrizio, Guglielmelli Paola, Zingariello Maria, Ghinassi Barbara, D'Amore Emanuela, Jimeno José, Vannucchi Alessandro M, Migliaccio Anna Rita

Abstract excerpt

The discovery of JAK2 mutations in Philadelphia-negative myeloproliferative neoplasms has prompted investigators to evaluate mutation-targeted treatments to restore hematopoietic cell functions in these diseases. However, the results of the first clinical trials with JAK2 inhibitors are not as pr...

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Source

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Identifiers

PMID: 20458749
DOI: 10.1002/jcp.22228
PMCID: PMC3780594

Genes

CXCR4
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20458749-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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CXCR4-independent rescue of the myeloproliferative defect of the Gata1low myelofibrosis mouse model by Aplidin.PMID 20458749Read ↗

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