Article
Variegation of the phenotype induced by the Gata1low mutation in mice of different genetic backgrounds.
Blood - 15 Dec 2005
Martelli Fabrizio, Ghinassi Barbara, Panetta Barbara, Alfani Elena, Gatta Valentina, Pancrazzi Alessandro, Bogani Costanza, Vannucchi Alessandro Maria, Paoletti Francesco, Migliaccio Giovanni, Migliaccio Anna Rita
Abstract excerpt
All mice harboring the X-linked Gata1low mutation in a predominantly CD1 background are born anemic and thrombocytopenic. They recover from anemia at 1 month of age but remain thrombocytopenic all their life and develop myelofibrosis, a syndrome similar to human idiopathic myelofibrosis, at 12 months. The effects of the genetic background on the myelofibrosis developed by Gata1low mice was assessed by introducing...
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