Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses.

PloS one - 3 May 2010

Härmä Ville, Virtanen Johannes, Mäkelä Rami, Happonen Antti, Mpindi John-Patrick, Knuuttila Matias, Kohonen Pekka, Lötjönen Jyrki, Kallioniemi Olli, Nees Matthias

Abstract excerpt

Prostate epithelial cells from both normal and cancer tissues, grown in three-dimensional (3D) culture as spheroids, represent promising in vitro models for the study of normal and cancer-relevant patterns of epithelial differentiation. We have developed the most comprehensive panel of miniaturized prostate cell culture models in 3D to date (n = 29), including many non-transformed and most currently available...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Shape
Share to Drug Combinations

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Laminin

Share to Mesoderm

Share to Phosphoinositide-3 Kinase Inhibitors

Share to Prostate

Share to Proteoglycans

Share to Spheroids, Cellular

Source

Open in PubMed Open full text

Identifiers

PMID: 20454659
DOI: 10.1371/journal.pone.0010431
PMCID: PMC2862707

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses.PMID 20454659Read ↗

Organoids: An Emerging Precision Medicine Model for Prostate Cancer ResearchSemantic proximity Read ↗

Prostate epithelial cell lines form spheroids with evidence of glandular differentiation in three-dimensional Matrigel cultures.Semantic proximity Read ↗

Epithelial-To-Mesenchymal Transition Markers and CD44 Isoforms Are Differently Expressed in 2D and 3D Cell Cultures of Prostate Cancer CellsSemantic proximity Read ↗

ECM-free patient-derived organoids preserve diverse prostate cancer lineages and uncover <i>in vitro</i> -enriched cell typesSemantic proximity Read ↗

Prostate Stroma Increases the Viability and Maintains the Branching Phenotype of Human Prostate OrganoidsSemantic proximity Read ↗

<em>In Vivo </em>Models for Prostate Cancer ResearchSemantic proximity Read ↗

Patient-derived prostate cancer organoids require α6-integrins for self-renewal and recapitulate genetic heterogeneity and histopathology of the original tumorsSemantic proximity Read ↗

Epidermal Growth Factor Is Essential for the Maintenance of Novel Prostate Epithelial Cells Isolated From Patient-Derived OrganoidsSemantic proximity Read ↗

Generation of prostate cancer assembloids modeling the patient-specific tumor microenvironmentSemantic proximity Read ↗

Multi-omics evaluation of cell lines as models for metastatic prostate cancer.Semantic proximity Read ↗

Differentiation of prostate epithelial cell cultures by matrigel/ stromal cell glandular reconstruction.Semantic proximity Read ↗

Multi-omics evaluation of cell lines as models for metastatic prostate cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.