Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p.

EMBO reports - 1 Dec 2003

Neumann Silvia, Petfalski Elisabeth, Brügger Britta, Grosshans Helge, Wieland Felix, Tollervey David, Hurt Ed

Abstract excerpt

The yeast ubiquitin-protein ligase Rsp5p regulates processes as diverse as polII transcription and endocytosis. Here, we identify Rsp5p in a screen for tRNA export (tex) mutants. The tex23-1/rsp5-3 mutant, which is complemented by RSP5, not only shows a strong nuclear accumulation of tRNAs at the restrictive temperature, but also is severely impaired in the nuclear export of mRNAs and 60S pre-ribosomal subunits....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endosomal Sorting Complexes Required for Transport
Share to Exocytosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ribosomes

Share to RNA Polymerase II

Share to RNA, Ribosomal

Share to RNA, Transfer

Share to Ubiquitin-Protein Ligase Complexes

Share to Yeasts

Source

Open in PubMed Open full text

Identifiers

PMID: 14608372
DOI: 10.1038/sj.embor.7400026
PMCID: PMC1326418

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p.PMID 14608372Read ↗

The ubiquitin ligase Rsp5 is required for ribosome stability in Saccharomyces cerevisiae.Semantic proximity Read ↗

Genome-wide screen uncovers novel pathways for tRNA processing and nuclear-cytoplasmic dynamics.Semantic proximity Read ↗

Genetic interactions show the importance of rRNA modification machinery for the role of Rps15p during ribosome biogenesis in S. cerevisiae.Semantic proximity Read ↗

Formation and nuclear export of preribosomes are functionally linked to the small-ubiquitin-related modifier pathway.Semantic proximity Read ↗

Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export.Semantic proximity Read ↗

Two mutant forms of the S1/TPR-containing protein Rrp5p affect the 18S rRNA synthesis in Saccharomyces cerevisiae.Semantic proximity Read ↗

Utp8p is a nucleolar tRNA-binding protein that forms a complex with components of the nuclear tRNA export machinery in Saccharomyces cerevisiae.Semantic proximity Read ↗

A putative ubiquitin ligase required for efficient mRNA export differentially affects hnRNP transport.Semantic proximity Read ↗

Rsp5 is required for the nuclear export of mRNA of HSF1 and MSN2/4 under stress conditions in Saccharomyces cerevisiae.Semantic proximity Read ↗

Nuclear Export of Pre-Ribosomal Subunits Requires Dbp5, but Not as an RNA-Helicase as for mRNA Export.Semantic proximity Read ↗

A genetic screen in Saccharomyces cerevisiae identifies new genes that interact with mex67-5, a temperature-sensitive allele of the gene encoding the mRNA export receptor.Semantic proximity Read ↗

MDP1, a Saccharomyces cerevisiae gene involved in mitochondrial/cytoplasmic protein distribution, is identical to the ubiquitin-protein ligase gene RSP5.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.