Article
Genetics of diabetes. Trans-racial gene mapping studies.
Bailliere's clinical endocrinology and metabolism - 1 Jun 1991
Mijovic C H, Barnett A H, Todd J A
Abstract excerpt
A major component of inherited susceptibility to IDDM is associated with one or more loci in the MHC. Identification of the primary susceptibility genes has been complicated by the low frequency of recombination, i.e. linkage disequilibrium, within the MHC. It is difficult to distinguish whether a detected genetic association with the disease is primary, or secondary due to linkage disequilibrium with an allele...
Topics
- Asian People
- Black People
- Chromosome Mapping
- Diabetes Mellitus, Type 1
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DQ beta-Chains
- HLA-DR Antigens
- HLA-DR Serological Subtypes
- HLA-DR3 Antigen