HLA class II polymorphism and genetic susceptibility to insulin-dependent diabetes mellitus.

doi:10.1007/978-3-642-75741-9_3

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Article

HLA class II polymorphism and genetic susceptibility to insulin-dependent diabetes mellitus.

Current topics in microbiology and immunology - 1 Jan 1990

Erlich H A

Abstract excerpt

As we have discussed previously (Horn et al. 1988a; Erlich et al. 1989b; Horn et al. 1988b), there are no unique class II sequences associated with IDDM, which suggests that "normal" class II alleles confer susceptibility. Given the estimates of concordance--under 50% of monozygotic twins and app...

Topics

Diabetes Mellitus, Type 1
Genes, MHC Class II
Genetic Predisposition to Disease
HLA-DP Antigens
HLA-DQ Antigens
HLA-DR Antigens
Histocompatibility Antigens Class II
Humans
Polymorphism, Genetic

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