Article
In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17.
Neuro-degenerative diseases - 1 Jan 2008
Ghetti Bernardino, Spina Salvatore, Murrell Jill R, Huey Edward D, Pietrini Pietro, Sweeney Brian, Wassermann Eric M, Keohane Catherine, Farlow Martin R, Grafman Jordan
Abstract excerpt
BACKGROUND: Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is associated with mutations in the Microtubule-Associated Protein Tau(MAPT) gene or the Progranulin(PGRN) gene. MAPT mutations lead to widespread deposition of hyperphosphorylated tau protein (FTDP-17T). PGRN mutations are associated with ubiquitin- and TDP-43-positive inclusions in the frontotemporal cortex, striatum and...
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