Article
Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma.
The Journal of allergy and clinical immunology - 1 May 2010
Dougherty Ryan H, Sidhu Sukhvinder S, Raman Kavita, Solon Margaret, Solberg Owen D, Caughey George H, Woodruff Prescott G, Fahy John V
Abstract excerpt
BACKGROUND: Previously, we found that mast cell tryptases and carboxypeptidase A3 (CPA3) are differentially expressed in the airway epithelium in asthmatic subjects. We also found that asthmatic subjects can be divided into 2 subgroups ("T(H)2 high" and "T(H)2 low" asthma) based on epithelial cell gene signatures for the activity of T(H)2 cytokines. OBJECTIVES: We sought to characterize intraepithelial mast cells...
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