Article
Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program.
American journal of respiratory and critical care medicine - 1 Feb 2011
Balzar Silvana, Fajt Merritt L, Comhair Suzy A A, Erzurum Serpil C, Bleecker Eugene, Busse William W, Castro Mario, Gaston Benjamin, Israel Elliot, Schwartz Lawrence B, Curran-Everett Douglas, Moore Charity G, Wenzel Sally E
Abstract excerpt
RATIONALE: Severe asthma (SA) remains poorly understood. Mast cells (MC) are implicated in asthma pathogenesis, but it remains unknown how their phenotype, location, and activation relate to asthma severity. OBJECTIVES: To compare MC-related markers measured in bronchoscopically obtained samples with clinically relevant parameters between normal subjects and subjects with asthma to clarify their pathobiologic...
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