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Article

Type 2 gene expression signature in severe asthma associates with more advanced airway remodeling

1 Jun 2025

Abstract excerpt

BACKGROUND: Asthma is a heterogeneous disease with various inflammatory subtypes, including the type-2 (T2) endotype associated with airway eosinophilia. Severe asthma is linked to reduced ventilatory function due to airway structural changes. This study compared the extent of airway remodeling in different immunological endotypes of asthma. METHODS: Severe asthma patients (n = 30) were stratified based on...

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PMID: 40506805
DOI: 10.1002/clt2.70060

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