Article
Dissection of the IgNAR V domain: molecular scanning and orthologue database mining define novel IgNAR hallmarks and affinity maturation mechanisms.
Journal of molecular biology - 9 Jul 2010
Fennell B J, Darmanin-Sheehan A, Hufton S E, Calabro V, Wu L, Müller M R, Cao W, Gill D, Cunningham O, Finlay W J J
Abstract excerpt
The shark antigen-binding V(NAR) domain has the potential to provide an attractive alternative to traditional biotherapeutics based on its small size, advantageous physiochemical properties, and unusual ability to target clefts in enzymes or cell surface molecules. The V(NAR) shares many of the properties of the well-characterised single-domain camelid V(H)H but is much less understood at the molecular level. We...
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