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Article

Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding.

Journal of molecular biology - 23 Mar 2007

Stanfield Robyn L, Dooley Helen, Verdino Petra, Flajnik Martin F, Wilson Ian A

Abstract excerpt

Sharks express an unusual heavy-chain isotype called IgNAR, whose variable regions bind antigen as independent soluble domains. To further probe affinity maturation of the IgNAR response, we structurally characterized the germline and somatically matured versions of a type II variable (V) region, both in the presence and absence of its antigen, hen egg-white lysozyme. Despite a disulfide bond linking...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17258766
DOI: 10.1016/j.jmb.2006.12.045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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