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Selection and affinity maturation of IgNAR variable domains targeting <i>Plasmodium falciparum</i> AMA1

20 Feb 2004

Abstract excerpt

The new antigen receptor (IgNAR) is an antibody unique to sharks and consists of a disulphide-bonded dimer of two protein chains, each containing a single variable and five constant domains. The individual variable (V(NAR)) domains bind antigen independently, and are candidates for the smallest antibody-based immune recognition units. We have previously produced a library of V(NAR) domains with extensive...

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PMID: 14997552
DOI: 10.1002/prot.20005

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