Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography.

doi:10.1038/s41467-021-27611-y

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Article

Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography.

Nature communications - 16 Dec 2021

Ubah Obinna C, Lake Eric W, Gunaratne Gihan S, Gallant Joseph P, Fernie Marie, Robertson Austin J, Marchant Jonathan S, Bold Tyler D, Langlois Ryan A, Matchett William E, Thiede Joshua M, Shi Ke, Yin Lulu, Moeller Nicholas H, Banerjee Surajit, Ferguson Laura, Kovaleva Marina, Porter Andrew J, Aihara Hideki, LeBeau Aaron M, Barelle Caroline J

Abstract excerpt

Single-domain Variable New Antigen Receptors (VNARs) from the immune system of sharks are the smallest naturally occurring binding domains found in nature. Possessing flexible paratopes that can recognize protein motifs inaccessible to classical antibodies, VNARs have yet to be exploited for the development of SARS-CoV-2 therapeutics. Here, we detail the identification of a series of VNARs from a VNAR phage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34916516
DOI: 10.1038/s41467-021-27611-y
PMCID: PMC8677774

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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