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Article

The hydroxy-methyl-glutaryl CoA reductase promoter polymorphism is associated with Alzheimer's risk and cognitive deterioration.

Neuroscience letters - 6 Apr 2007

Porcellini Elisa, Calabrese Elena, Guerini Franca, Govoni Marzia, Chiappelli Martina, Tumini Emanuela, Morgan Kevin, Chappell Sally, Kalsheker Noor, Franceschi Massimo, Licastro Federico

Abstract excerpt

A link between cholesterol and Alzheimer's disease (AD) had been suggested. Hydroxy-methylglutaryl-coenzyme A reductase (HMGCR) is the rate limiting enzyme in the synthesis of cholesterol. A single nucleotide polymorphism (SNP) in the promoter of this gene, never described in Italian AD populatio...

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Source

Identifiers

PMID: 17284348
DOI: 10.1016/j.neulet.2007.01.046

Genes

HMGCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17284348-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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