Article
ILK mediates LPS-induced vascular adhesion receptor expression and subsequent leucocyte trans-endothelial migration.
Cardiovascular research - 1 May 2010
Hortelano Sonsoles, López-Fontal Raquel, Través Paqui G, Villa Natividad, Grashoff Carsten, Boscá Lisardo, Luque Alfonso
Abstract excerpt
AIMS: The inflammatory response to injurious agents is tightly regulated to avoid adverse consequences of inappropriate leucocyte accumulation or failed resolution. Lipopolysaccharide (LPS)-activated endothelium recruits leucocytes to the inflamed tissue through controlled expression of membrane-associated adhesion molecules. LPS responses in macrophages are known to be regulated by integrin-linked kinase (ILK);...
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