Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lipopolysaccharide induces a fibrotic-like phenotype in endothelial cells.

Journal of cellular and molecular medicine - 1 Jun 2013

Echeverría César, Montorfano Ignacio, Sarmiento Daniela, Becerra Alvaro, Nuñez-Villena Felipe, Figueroa Xavier F, Cabello-Verrugio Claudio, Elorza Alvaro A, Riedel Claudia, Simon Felipe

Abstract excerpt

Endothelial dysfunction is crucial in endotoxaemia-derived sepsis syndrome pathogenesis. It is well accepted that lipopolysaccharide (LPS) induces endothelial dysfunction through immune system activation. However, LPS can also directly generate actions in endothelial cells (ECs) in the absence of participation by immune cells. Although interactions between LPS and ECs evoke endothelial death, a significant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lipopolysaccharides
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibrosis

Share to Human Umbilical Vein Endothelial Cells

Share to Receptor, Transforming Growth Factor-beta Type I

Share to Receptors, Transforming Growth Factor beta

Share to Tissue Culture Techniques

Share to Umbilical Veins

Source

Open in PubMed Open full text

Identifiers

PMID: 23635013
DOI: 10.1111/jcmm.12066
PMCID: PMC3823184

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lipopolysaccharide induces a fibrotic-like phenotype in endothelial cells.PMID 23635013Read ↗

Endothelial Responses in Sepsis.Semantic proximity Read ↗

rhMFGE8 Attenuates Endothelial-to-Mesenchymal Transition in Acute Lung Injury Induced by Lipopolysaccharide Through the BMP/Smad1/4/5/Snail Signalling PathwaySemantic proximity Read ↗

Lipopolysaccharide exposure modulates the contractile and migratory phenotypes of vascular smooth muscle cells.Semantic proximity Read ↗

Molecular basis of endothelial dysfunction in sepsis.Semantic proximity Read ↗

ILK mediates LPS-induced vascular adhesion receptor expression and subsequent leucocyte trans-endothelial migration.Semantic proximity Read ↗

Heterogeneity in Endothelial Responsiveness to Cytokines, Molecular Causes, and Pharmacological ConsequencesSemantic proximity Read ↗

Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis.Semantic proximity Read ↗

Endothelial-to-mesenchymal transition in lipopolysaccharide-induced acute lung injury drives a progenitor cell-like phenotype.Semantic proximity Read ↗

TIRAP mediates endotoxin-induced NF-kappaB activation and apoptosis in endothelial cells.Semantic proximity Read ↗

Development of a zebrafish sepsis model for high-throughput drug discovery.Semantic proximity Read ↗

Endothelial cells require STAT3 for protection against endotoxin-induced inflammation.Semantic proximity Read ↗

The Immunophilin Protein FKBPL and its Peptide Derivatives are Novel Regulators of Vascular Integrity and Inflammation via Nf-κB SignalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.