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Article

A common genetic variant is associated with adult and childhood obesity.

Science (New York, N.Y.) - 14 Apr 2006

Herbert Alan, Gerry Norman P, McQueen Matthew B, Heid Iris M, Pfeufer Arne, Illig Thomas, Wichmann H-Erich, Meitinger Thomas, Hunter David, Hu Frank B, Colditz Graham, Hinney Anke, Hebebrand Johannes, Koberwitz Kerstin, Zhu Xiaofeng, Cooper Richard, Ardlie Kristin, Lyon Helen, Hirschhorn Joel N, Laird Nan M, Lenburg Marc E, Lange Christoph, Christman Michael F

Abstract excerpt

Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with...

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Identifiers

PMID: 16614226
DOI: 10.1126/science.1124779

Genes

INSIG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16614226-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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