Article
An African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans.
PLoS genetics - 1 Mar 2009
Kelley James M, Hughes Laura B, Faggard Jeffrey D, Danila Maria I, Crawford Monica H, Edberg Yuanqing, Padilla Miguel A, Tiwari Hemant K, Westfall Andrew O, Alarcón Graciela S, Conn Doyt L, Jonas Beth L, Callahan Leigh F, Smith Edwin A, Brasington Richard D, Allison David B, Kimberly Robert P, Moreland Larry W, Edberg Jeffrey C, Bridges S Louis
Abstract excerpt
Cytotoxic T-lymphocyte associated protein 4 (CTLA4) is a negative regulator of T-cell proliferation. Polymorphisms in CTLA4 have been inconsistently associated with susceptibility to rheumatoid arthritis (RA) in populations of European ancestry but have not been examined in African Americans. The prevalence of RA in most populations of European and Asian ancestry is approximately 1.0%; RA is purportedly less...
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