Article
beta(2)-adrenergic receptor promoter haplotype influences spirometric response during an acute asthma exacerbation.
Clinical and translational science - 1 Sept 2008
Moore Paul E, Williams Scott M, Gebretsadik Tebeb, Jiang Lan, Minton Patricia L, Shintani Ayumi, Phillips Iii John A, Dawson Elliott P, Hartert Tina V
Abstract excerpt
Genetic variants in the beta(2)-adrenergic receptor (ADRB2) coding block have been associated with different parameters of asthma severity, but there is no consensus on which variants are most important. Our objective was to determine whether the genetic variants in the 5'- or 3'-flanking regions of ADRB2 impact the response to therapy. DNA was obtained initially from 72 adults hospitalized for an asthma...
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