Article
Bronchodilator response in relation to beta2-adrenoceptor haplotype in patients with asthma.
American journal of respiratory and critical care medicine - 15 Sept 2005
Taylor D Robin, Epton Michael J, Kennedy Martin A, Smith Andrew D, Iles Steven, Miller Allison L, Littlejohn Matthew D, Cowan Jan O, Hewitt Tracey, Swanney Maureen P, Brassett Karen P, Herbison G Peter
Abstract excerpt
RATIONALE: Genetic variation of the beta2-adrenoceptor (ADRB2) influences receptor function in vitro. There are reports that, in vivo, bronchodilator response is related to ADRB2 genotype, and that clinical outcomes during chronic therapy with beta2-agonist drugs are also influenced by genotype....
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