Article
Molecular-based haplotype analysis of the beta 2-adrenergic receptor gene (ADRB2) in Japanese asthmatic and non-asthmatic subjects.
Allergology international : official journal of the Japanese Society of Allergology - 1 Jun 2006
Munakata Mitsuru, Harada Yosuke, Ishida Takashi, Saito Junpei, Nagabukuro Akira, Matsushita Hiroshi, Koga Nobuyuki, Ohsaki Masaaki, Imagawa Kenichi, Shiratsuchi Takayuki
Abstract excerpt
BACKGROUND: The beta2-adrenergic receptor gene (ADRB2) is a target molecule of beta2-agonists. Single nucleotide polymorphisms (SNPs) in the ADRB2 are related to the effectiveness of beta2-agonists. However, there are some discrepancies in the results of pharmacogenetic studies of ADRB2 among different ethnic groups. The aims of this study were to determine the ADRB2 haplotypes and diplotypes in Japanese...
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