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Article

ErbB2 Induces Notch1 Activity and Function in Breast Cancer Cells

1 Sept 2008

Abstract excerpt

The ErbB2 (Her2/neu epidermal growth receptor family) oncogene is overexpressed in 30% to 40% of human breast cancers. Cyclin D1 is the regulatory subunit of the holoenzyme that phosphorylates and inactivates the retinoblastoma (pRb) tumor suppressor and is an essential downstream target of ErbB2-induced tumor growth. Herein, we demonstrate that ErbB2 induces the activity of the Notch signaling pathway. ErbB2...

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PMID: 20443831
DOI: 10.1111/j.1752-8062.2008.00041.x

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